POU4F3

Across TCGA cell cohorts, POU4F3 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU4F3-associated genes across cancer lineages are CDY2A, OR14A16, and KRTAP9-2. Each is linked with POU4F3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU4F3-to-partner and partner-to-POU4F3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDY2A grouped by POU4F3-low versus POU4F3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU4F3→partner) and Y-score (partner→POU4F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CDY2A →	+0.005	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	OR14A16 →	+0.017	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.032	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	IFNL4 →	+0.018	+4.191	.004	.007	3	1
UPPER_AERODIGESTIVE_TRACT	GPR88 →	+0.036	+4.870	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.022	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

CDY2A by POU4F3 expression — BLOOD_Lymphoma

Explore this box plot interactively →