PAGE family member 3Genealiases: CT16.6 · GAGED1 · PAGE-3
Q-omics provides the consensus-scored PAGE3 profile across patient tissues and cancer cell-line models. PAGE3 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, PAGE3 is differentially expressed in 4, with the highest sampling consensus in KIRC. Additionally, PAGE3 RNA expression shows 6,294 significant gene co-expression associations, with the highest sampling consensus in COAD. Together, these results highlight KIRC, and COAD as cancer lineages where PAGE3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PAGE3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PAGE3 survival associations across molecular data types. PAGE3 RNA expression shows survival associations in the most cancer types (17), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PAGE3 RNA expression–survival associations across cancer types. High PAGE3 expression shows unfavorable associations in KIRC, CESC, KICH, MESO, UCS and LUSC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KIRC as the clearest survival context for PAGE3 RNA expression.
This table summarizes PAGE3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for PAGE3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PAGE3 shows lower tumor expression in KIRC and KICH and higher tumor expression in HNSC and LIHC. The KIRC box plot shows higher PAGE3 RNA expression in normal versus tumor tissue (log2 FC = −0.048, t-test p < 0.001).
This table shows molecular features associated with PAGE3 in patient tissues and cancer cell lines. In patient samples, PAGE3 shows the broadest associations at the RNA and protein expression levels, with COAD recurring as the lineage with the largest associated feature set. In cancer cell lines, PAGE3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and BREAST.
