Across TCGA patient cohorts, PAGE3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAGE3-associated genes across cancer lineages are Heregulin, PCNA, and Caspase-8. Each is linked with PAGE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAGE3-to-partner and partner-to-PAGE3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAGE3→partner) and Y-score (partner→PAGE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.162	-3.321	.006	.010	3	1
UCEC	PCNA →	+0.287	+2.459	.005	.020	3	1
UCEC	Caspase-8 →	-0.328	-3.584	.006	.002	3	1
UCEC	eIF4E →	+0.228	+2.459	.025	.020	2	1
UCEC	JNK2 →	+0.298	+2.817	.001	.036	2	1
UCEC	Rab11 →	-0.174	-3.584	.013	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

PAGE3 survival (RNA) · tumor vs normal (RNA) · all PAGE3 data types