Across TCGA pan-cancer cohorts, PAGE3 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PAGE3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PAGE3 RNA is repressed in tumor relative to normal tissue. In most cancer types PAGE3 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where PAGE3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAGE3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.048	<.001	9	view →
HNSC	Female	II,III,IV	+0.055	.020	2	view →
LIHC	Male	All	+0.020	.042	2	view →
KICH	All	II,III,IV	−0.075	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PAGE3 RNA expression & survival · all PAGE3 data types