Across TCGA pan-cancer cohorts, PAGE3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PAGE3 data layer compared with 17 for mass-spec protein.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher PAGE3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PAGE3 expression acts as an unfavorable survival marker.
BLCA, CESC, and SKCM are the cancer types where PAGE3 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.