Q-omics provides the consensus-scored OR8D4 profile across patient tissues and cancer cell-line models. OR8D4 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in THCA. Among the 18 cancer types available for tumor–normal comparison, OR8D4 is differentially expressed in 2, with the highest sampling consensus in COAD. Additionally, OR8D4 RNA expression shows 7,837 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight THCA, COAD, and PDAC as cancer lineages where OR8D4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OR8D4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OR8D4 survival associations across molecular data types. OR8D4 RNA expression shows survival associations in the most cancer types (16), followed by mutation status (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OR8D4 RNA expression–survival associations across cancer types. High OR8D4 expression shows unfavorable associations in THCA, BLCA, STAD, BRCA, PAAD and UVM. The THCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THCA as the clearest survival context for OR8D4 RNA expression.
This table summarizes OR8D4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for OR8D4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OR8D4 shows lower tumor expression in COAD and KIRC. The COAD box plot shows higher OR8D4 RNA expression in normal versus tumor tissue (log2 FC = −0.030, t-test p = .026).
This table shows molecular features associated with OR8D4 in patient tissues and cancer cell lines. In patient samples, OR8D4 shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set. In cancer cell lines, OR8D4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Lymphoma, while CRISPR and shRNA rows add functional-dependency signals in SKIN and LARGE_INTESTINE.
