Across TCGA pan-cancer cohorts, OR8D4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR8D4’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where OR8D4 RNA is repressed in tumor relative to normal tissue. In most cancer types OR8D4 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.
COAD and KIRC are the cancer types where OR8D4 tumor–normal differential expression is most reproducible.