olfactory receptor family 10 subfamily G member 8Genealiases: OR11-274 · OR11-282
Q-omics provides the consensus-scored OR10G8 profile across patient tissues and cancer cell-line models. OR10G8 expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, OR10G8 is differentially expressed in 2, with the highest sampling consensus in COAD. Additionally, OR10G8 RNA expression shows 7,210 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight UCEC, COAD, and PDAC as cancer lineages where OR10G8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OR10G8 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OR10G8 survival associations across molecular data types. OR10G8 RNA expression shows survival associations in the most cancer types (7), followed by mutation status (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OR10G8 RNA expression–survival associations across cancer types. High OR10G8 expression shows unfavorable associations in UCEC, ESCA, LUSC, PAAD and LGG, but favorable associations in COAD. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify UCEC as the clearest survival context for OR10G8 RNA expression.
This table summarizes OR10G8 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for OR10G8. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OR10G8 shows lower tumor expression in COAD and BRCA. The COAD box plot shows higher OR10G8 RNA expression in normal versus tumor tissue (log2 FC = −0.009, t-test p = .043).
This table shows molecular features associated with OR10G8 in patient tissues and cancer cell lines. In patient samples, OR10G8 shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set. In cancer cell lines, OR10G8 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and SKIN.
