neurexophilin and PC-esterase domain family member 3Genealiases: FAM55C · MST115 · MSTP115
Q-omics provides the consensus-scored NXPE3 profile across patient tissues and cancer cell-line models. NXPE3 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, NXPE3 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, NXPE3 RNA expression shows 20,845 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight SKCM, HNSC, and GBM as cancer lineages where NXPE3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NXPE3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NXPE3 survival associations across molecular data types. NXPE3 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (7) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NXPE3 RNA expression–survival associations across cancer types. High NXPE3 expression shows unfavorable associations in HNSC, MESO and UCEC, but favorable associations in SKCM, UCS and LUAD. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for NXPE3 RNA expression.
This table summarizes NXPE3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for NXPE3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NXPE3 shows lower tumor expression in LUAD, THCA, COAD, KICH and UCEC and higher tumor expression in HNSC. The HNSC box plot shows higher NXPE3 RNA expression in tumor versus normal tissue (log2 FC = +1.362, t-test p < 0.001).
This table shows molecular features associated with NXPE3 in patient tissues and cancer cell lines. In patient samples, NXPE3 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, NXPE3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and BLOOD_Lymphoma.
