NXPE3

Across TCGA cell cohorts, NXPE3 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NXPE3-associated genes across cancer lineages are FOXR2, GZMK, and TMEM174. Each is linked with NXPE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPE3-to-partner and partner-to-NXPE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXR2 grouped by NXPE3-low versus NXPE3-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPE3→partner) and Y-score (partner→NXPE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FOXR2 →	+0.006	+5.000	<.001	.006	3	2
PANCREAS	GZMK →	+0.006	+5.614	<.001	.002	3	1
SOFT_TISSUE	TMEM174 →	+0.018	+4.930	.004	.008	3	1
BLOOD_Leukemia	IFNG →	+0.184	+4.567	<.001	.001	3	1
BLOOD_Leukemia	CYP4A22 →	+0.039	+3.807	<.001	.007	3	1
BLOOD_Leukemia	DELEC1 →	+0.967	+3.855	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

FOXR2 by NXPE3 expression — PANCREAS

Explore this box plot interactively →