NXPE3

Across TCGA patient cohorts, NXPE3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXPE3-associated genes across cancer lineages are GAPDH, 14-3-3_beta, and EGFR_pY1068. Each is linked with NXPE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPE3-to-partner and partner-to-NXPE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by NXPE3-low versus NXPE3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPE3→partner) and Y-score (partner→NXPE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.622	+3.584	.001	.002	3	2
UCEC	14-3-3_beta →	-0.104	-2.673	.005	.005	3	1
UCEC	EGFR_pY1068 →	-0.248	-1.700	.007	.042	3	1
UCEC	eIF4E →	+0.186	+2.700	.016	.006	3	1
UCEC	ERK2 →	+0.219	+2.584	.001	.010	3	1
UCEC	ETS-1 →	+0.261	+2.459	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

GAPDH by NXPE3 expression — UCEC

Explore this box plot interactively →