NXPE3

Across TCGA patient cohorts, NXPE3 mutation is significantly associated with the RNA expression of many other genes, with 2,708 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXPE3-associated genes across cancer lineages are MIR374A, RNA5SP463, and IGHD2-2. Each is linked with NXPE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPE3-to-partner and partner-to-NXPE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR374A grouped by NXPE3-low versus NXPE3-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPE3→partner) and Y-score (partner→NXPE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR374A →	+0.425	+6.169	<.001	<.001	3	2
LIHC	RNA5SP463 →	+0.457	+5.008	<.001	.004	3	2
LIHC	IGHD2-2 →	+1.671	+5.230	<.001	.001	3	2
CESC	RNU6-1245P →	+0.369	+5.060	<.001	.001	3	2
UCEC	ESS2 →	+0.227	+1.949	.007	.001	3	2
UCEC	HIRA →	+0.429	+3.136	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,708 associations by consensus.

MIR374A by NXPE3 expression — LIHC

Explore this box plot interactively →