NACHT and WD repeat domain containing 1Genealiases: []
Q-omics provides the consensus-scored NWD1 profile across patient tissues and cancer cell-line models. NWD1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, NWD1 is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, NWD1 RNA expression shows 14,910 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight HNSC, THCA, and KIRP as cancer lineages where NWD1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NWD1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NWD1 survival associations across molecular data types. NWD1 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NWD1 RNA expression–survival associations across cancer types. High NWD1 expression shows unfavorable associations in ESCA, but favorable associations in HNSC, COAD, UCEC, KIRC and STAD. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for NWD1 RNA expression.
This table summarizes NWD1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for NWD1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NWD1 shows lower tumor expression in THCA, LUSC, LUAD, STAD, BRCA and KIRC. The THCA box plot shows higher NWD1 RNA expression in normal versus tumor tissue (log2 FC = −2.195, t-test p < 0.001).
This table shows molecular features associated with NWD1 in patient tissues and cancer cell lines. In patient samples, NWD1 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, NWD1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BONE and LARGE_INTESTINE.
