Across TCGA patient cohorts, NWD1 mutation is significantly associated with the RNA expression of many other genes, with 6,946 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NWD1-associated genes across cancer lineages are HMG20B, SLC7A11, and EIF4E. Each is linked with NWD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NWD1-to-partner and partner-to-NWD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NWD1→partner) and Y-score (partner→NWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMG20B →	+0.402	+3.343	<.001	<.001	3	5
COAD	SLC7A11 →	+1.132	+2.874	<.001	<.001	3	4
UCEC	EIF4E →	+0.320	+2.684	.001	<.001	3	4
COAD	NEIL2 →	+0.583	+2.973	<.001	<.001	3	4
UCEC	RCHY1 →	+0.287	+1.506	.006	.003	3	4
UCEC	H2AZ1 →	+0.505	+2.147	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,946 associations by consensus.

Exploration

NWD1 survival (RNA) · tumor vs normal (RNA) · all NWD1 data types