nuclear receptor interacting protein 1Genealiases: CAKUT3 · RIP140
Q-omics provides the consensus-scored NRIP1 profile across patient tissues and cancer cell-line models. NRIP1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, NRIP1 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, NRIP1 RNA expression shows 20,100 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight MESO, HNSC, and ACC as cancer lineages where NRIP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NRIP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NRIP1 survival associations across molecular data types. NRIP1 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (5) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NRIP1 RNA expression–survival associations across cancer types. High NRIP1 expression shows unfavorable associations in MESO, PAAD and KIRP, but favorable associations in KIRC, BRCA and UCEC. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify MESO as the clearest survival context for NRIP1 RNA expression.
This table summarizes NRIP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for NRIP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NRIP1 shows lower tumor expression in KICH, COAD and READ and higher tumor expression in HNSC, THCA and BLCA. The HNSC box plot shows higher NRIP1 RNA expression in tumor versus normal tissue (log2 FC = +1.110, t-test p < 0.001).
This table shows molecular features associated with NRIP1 in patient tissues and cancer cell lines. In patient samples, NRIP1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, NRIP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Lymphoma, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BONE.
