NRIP1

Across TCGA patient cohorts, NRIP1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRIP1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Caspase-7-cleavedD198, and CDK1. Each is linked with NRIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NRIP1-to-partner and partner-to-NRIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by NRIP1-low versus NRIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRIP1→partner) and Y-score (partner→NRIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.251	-1.514	.044	.014	3	3
UCEC	Caspase-7-cleavedD198 →	+0.846	+1.874	<.001	<.001	3	3
UCEC	CDK1 →	+0.108	+1.137	.010	.037	3	3
UCEC	p62 Lck ligand →	+0.331	+3.321	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.189	-1.678	<.001	<.001	3	2
UCEC	TFRC →	+0.484	+1.494	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

p38-MAPK_pT180_Y182 by NRIP1 expression — UCEC

Explore this box plot interactively →