neuromedin B receptorGenealiases: BB1 · BB1R · BRS1 · NMB-R
Q-omics provides the consensus-scored NMBR profile across patient tissues and cancer cell-line models. NMBR expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, NMBR is differentially expressed in 12, with the highest sampling consensus in THCA. Additionally, NMBR RNA expression shows 14,589 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRC, THCA, and THYM as cancer lineages where NMBR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NMBR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NMBR survival associations across molecular data types. NMBR RNA expression shows survival associations in the most cancer types (21), followed by mutation status (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NMBR RNA expression–survival associations across cancer types. High NMBR expression shows unfavorable associations in LIHC, MESO and OV, but favorable associations in KIRC, HNSC and BRCA. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify KIRC as the clearest survival context for NMBR RNA expression.
This table summarizes NMBR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for NMBR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NMBR shows lower tumor expression in THCA, KICH, KIRC, BRCA, LUAD and LUSC. The THCA box plot shows higher NMBR RNA expression in normal versus tumor tissue (log2 FC = −0.349, t-test p < 0.001).
This table shows molecular features associated with NMBR in patient tissues and cancer cell lines. In patient samples, NMBR shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, NMBR RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in BREAST and LARGE_INTESTINE.
