NMBR

Across TCGA cell cohorts, NMBR mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NMBR-associated genes across cancer lineages are TDRD15, UBTFL1, and BMP15. Each is linked with NMBR in more than 1 cancer types. Because this analysis shows association rather than direction, both NMBR-to-partner and partner-to-NMBR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TDRD15 grouped by NMBR-low versus NMBR-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMBR→partner) and Y-score (partner→NMBR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TDRD15 →	+0.029	+4.930	<.001	.008	3	1
SOFT_TISSUE	UBTFL1 →	+0.043	+5.369	<.001	.004	3	1
BLOOD_Lymphoma	BMP15 →	+0.021	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	VSTM1 →	+0.035	+4.714	.003	.002	3	1
LARGE_INTESTINE	OLFM3 →	+1.118	+3.847	.002	.001	3	1
LARGE_INTESTINE	ERICH3 →	+0.121	+3.662	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

TDRD15 by NMBR expression — SOFT_TISSUE

Explore this box plot interactively →