NMBR

Across TCGA patient cohorts, NMBR mutation is significantly associated with the RNA expression of many other genes, with 1,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMBR-associated genes across cancer lineages are COQ5, MRPL18, and PSMC3IP. Each is linked with NMBR in more than 1 cancer types. Because this analysis shows association rather than direction, both NMBR-to-partner and partner-to-NMBR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COQ5 grouped by NMBR-low versus NMBR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMBR→partner) and Y-score (partner→NMBR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	COQ5 →	+0.351	+3.729	.006	<.001	3	2
UCEC	MRPL18 →	+0.363	+2.425	.001	.001	3	2
UCEC	PSMC3IP →	+0.619	+2.831	<.001	.001	3	2
UCEC	MED27 →	+0.458	+2.991	<.001	<.001	3	2
SKCM	FMO4 →	-0.739	-3.788	<.001	<.001	3	2
UCEC	DTYMK →	+0.613	+3.272	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,739 associations by consensus.

COQ5 by NMBR expression — SKCM

Explore this box plot interactively →