nucleolar protein interacting with the FHA domain of MKI67Genealiases: MKI67IP · Nop15 · Nopp34
Q-omics provides the consensus-scored NIFK profile across patient tissues and cancer cell-line models. NIFK expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, NIFK is differentially expressed in 15, with the highest sampling consensus in HNSC. Additionally, NIFK protein abundance shows 29,998 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRP, HNSC, and GBM as cancer lineages where NIFK shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NIFK — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NIFK survival associations across molecular data types. NIFK RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NIFK RNA expression–survival associations across cancer types. High NIFK expression shows unfavorable associations in KIRP, ACC, HNSC, KICH, LIHC and LUAD. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for NIFK RNA expression.
This table summarizes NIFK tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for NIFK. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NIFK shows higher tumor expression in HNSC, KIRC, LIHC, STAD, COAD and LUAD. The HNSC box plot shows higher NIFK RNA expression in tumor versus normal tissue (log2 FC = +1.249, t-test p < 0.001).
This table shows molecular features associated with NIFK in patient tissues and cancer cell lines. In patient samples, NIFK shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, NIFK RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in OVARY and BLOOD_Lymphoma.
