NIFK

Across TCGA pan-cancer cohorts, NIFK RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NIFK’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NIFK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NIFK is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where NIFK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NIFK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.249	<.001	12	view →
KIRC	Female	III,IV	+0.842	<.001	12	view →
LIHC	Male	II,III,IV	+1.364	<.001	9	view →
STAD	Female	All	+1.258	<.001	9	view →
COAD	Male	All	+1.038	<.001	9	view →
LUAD	Male	II,III,IV	+0.927	<.001	9	view →
LUSC	Male	II,III,IV	+1.428	<.001	8	view →
KIRP	All	II,III,IV	+0.811	<.001	8	view →
BLCA	All	III,IV	+0.597	.004	8	view →
READ	All	II,III,IV	+1.177	<.001	7	view →
BRCA	All	II,III,IV	+0.389	<.001	6	view →
CHOL	Male	All	+2.275	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NIFK–HNSC

Open the HNSC breakdown →