nudE neurodevelopment protein 1 like 1Genealiases: EOPA · MITAP1 · NDE1L1 · NDE2 · NUDEL
Q-omics provides the consensus-scored NDEL1 profile across patient tissues and cancer cell-line models. NDEL1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, NDEL1 is differentially expressed in 12, with the highest sampling consensus in KIRC. Additionally, NDEL1 protein abundance shows 23,385 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight ACC, KIRC, and GBM as cancer lineages where NDEL1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NDEL1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NDEL1 survival associations across molecular data types. NDEL1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NDEL1 RNA expression–survival associations across cancer types. High NDEL1 expression shows unfavorable associations in ACC, MESO, BLCA, LUAD and LGG, but favorable associations in KIRC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for NDEL1 RNA expression.
This table summarizes NDEL1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for NDEL1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NDEL1 shows lower tumor expression in KICH, LUAD, BRCA and LUSC and higher tumor expression in KIRC and HNSC. The KIRC box plot shows higher NDEL1 RNA expression in tumor versus normal tissue (log2 FC = +0.602, t-test p < 0.001).
This table shows molecular features associated with NDEL1 in patient tissues and cancer cell lines. In patient samples, NDEL1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, NDEL1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LARGE_INTESTINE.
