NDEL1

Across TCGA patient cohorts, NDEL1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDEL1-associated genes across cancer lineages are GAPDH, 14-3-3_beta, and EGFR_pY1068. Each is linked with NDEL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDEL1-to-partner and partner-to-NDEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by NDEL1-low versus NDEL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDEL1→partner) and Y-score (partner→NDEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.485	+1.700	.033	.044	3	2
UCEC	14-3-3_beta →	-0.100	-3.143	.019	.018	3	1
UCEC	EGFR_pY1068 →	-0.303	-3.584	.004	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.217	-3.584	.002	.002	3	1
UCEC	JNK2 →	+0.325	+2.222	<.001	.011	3	1
UCEC	MEK1 →	+0.322	+1.700	.038	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

GAPDH by NDEL1 expression — UCEC

Explore this box plot interactively →