NDEL1

Across TCGA pan-cancer cohorts, NDEL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NDEL1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NDEL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NDEL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where NDEL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.296	.005	60	view →
UCEC	DFS	Quartile	All	1.000	0.793	.005	18	view →
LUAD	DFS	Median	II,III,IV	0.276	0.742	.004	9	view →
CCRCC	DFS	Quartile	II,III,IV	0.888	0.336	.025	4	view →
GBM	DFS	Quartile	All	0.798	0.692	.035	1	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.538	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NDEL1–HNSC (OS)

Open the HNSC breakdown →