MTUS1

Across TCGA patient cohorts, MTUS1 mutation is significantly associated with the RNA expression of many other genes, with 1,925 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTUS1-associated genes across cancer lineages are TYMSOS, PTGS1, and RNU6-839P. Each is linked with MTUS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTUS1-to-partner and partner-to-MTUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMSOS grouped by MTUS1-low versus MTUS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTUS1→partner) and Y-score (partner→MTUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYMSOS →	+0.530	+1.858	<.001	.004	3	3
UCEC	PTGS1 →	-0.865	-1.515	.006	.007	3	3
STAD	RNU6-839P →	+0.260	+3.274	.001	.006	3	3
KIRP	OTX2P1 →	+0.219	+4.770	<.001	.006	3	3
SKCM	RPL21P31 →	+0.062	+2.062	.001	.005	3	2
KIRP	H3P18 →	+0.153	+4.628	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,925 associations by consensus.

TYMSOS by MTUS1 expression — UCEC

Explore this box plot interactively →