MTUS1

Across TCGA pan-cancer cohorts, MTUS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MTUS1 data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MTUS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MTUS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UVM show a favorable association.

KIRC, UVM, and HNSC are the cancer types where MTUS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.737	0.538	<.001	137	view →
UVM	OS	Median	All	0.786	0.436	<.001	123	view →
HNSC	DFS	Quartile	All	0.727	0.501	<.001	91	view →
STAD	DFS	Tertile	IV	0.142	0.674	.004	42	view →
SKCM	OS	Tertile	All	0.440	0.263	<.001	41	view →
LUAD	DFS	Tertile	All	0.503	0.246	<.001	41	view →
KIRP	OS	Quartile	All	0.449	0.746	.009	37	view →
COAD	OS	Median	All	0.893	0.715	.001	31	view →
LGG	DFS	Median	All	0.779	0.880	<.001	29	view →
READ	OS	Quartile	II,III,IV	0.957	0.646	.002	23	view →
PRAD	DFS	Median	All	0.963	0.900	<.001	18	view →
THCA	OS	Median	II,III,IV	0.996	0.956	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MTUS1–KIRC (OS)

Open the KIRC breakdown →