Q-omics provides the consensus-scored MRPS14 profile across patient tissues and cancer cell-line models. MRPS14 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, MRPS14 is differentially expressed in 13, with the highest sampling consensus in KICH. Additionally, MRPS14 protein abundance shows 20,433 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRC, KICH, and LSCC as cancer lineages where MRPS14 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MRPS14 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MRPS14 survival associations across molecular data types. MRPS14 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (2) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MRPS14 RNA expression–survival associations across cancer types. High MRPS14 expression shows unfavorable associations in UVM, ACC, LIHC, STAD and KICH, but favorable associations in KIRC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for MRPS14 RNA expression.
This table summarizes MRPS14 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 6. The strongest signals are observed in THCA for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for MRPS14. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MRPS14 shows lower tumor expression in KICH, THCA and KIRC and higher tumor expression in HNSC, LIHC and COAD. The KICH box plot shows higher MRPS14 RNA expression in normal versus tumor tissue (log2 FC = −1.519, t-test p < 0.001).
This table shows molecular features associated with MRPS14 in patient tissues and cancer cell lines. In patient samples, MRPS14 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, MRPS14 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and UPPER_AERODIGESTIVE_TRACT.
