MRPS14

Across TCGA patient cohorts, MRPS14 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS14-associated genes across cancer lineages are FoxM1, p90 RSK, and STAT3_pY705. Each is linked with MRPS14 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS14-to-partner and partner-to-MRPS14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MRPS14-low versus MRPS14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS14→partner) and Y-score (partner→MRPS14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.339	+3.000	.023	.037	3	1
UCEC	p90 RSK →	+0.231	+3.013	.037	.019	3	1
UCEC	STAT3_pY705 →	-0.516	-3.000	<.001	.037	3	1
UCEC	C-Raf_pS338 →	-0.157	-3.000	<.001	.037	3	1
UCEC	eIF4E →	+0.239	+3.000	.049	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FoxM1 by MRPS14 expression — UCEC

Explore this box plot interactively →