MRPS14

Across TCGA pan-cancer cohorts, MRPS14 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPS14 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRPS14 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MRPS14 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where MRPS14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.915	0.663	.001	36	view →
PDAC	DFS	Tertile	II,III,IV	0.574	0.295	.008	31	view →
HNSC	OS	Tertile	II,III,IV	1.000	0.928	.017	21	view →
CCRCC	OS	Median	III,IV	0.707	0.939	.008	15	view →
LUAD	DFS	Median	All	0.936	0.890	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPS14–LSCC (OS)

Open the LSCC breakdown →