Morf4 family associated protein 1Genealiases: PAM14 · PGR1
Q-omics provides the consensus-scored MRFAP1 profile across patient tissues and cancer cell-line models. MRFAP1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, MRFAP1 is differentially expressed in 10, with the highest sampling consensus in LIHC. Additionally, MRFAP1 RNA expression shows 19,008 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight UCEC, LIHC, and ACC as cancer lineages where MRFAP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MRFAP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MRFAP1 survival associations across molecular data types. MRFAP1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (4) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MRFAP1 RNA expression–survival associations across cancer types. High MRFAP1 expression shows unfavorable associations in LIHC, LUAD, MESO and HNSC, but favorable associations in UCEC and KIRC. The UCEC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for MRFAP1 RNA expression.
This table summarizes MRFAP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 3. The strongest signals are observed in THCA for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for MRFAP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MRFAP1 shows lower tumor expression in THCA, KICH, LUAD and BLCA and higher tumor expression in LIHC and HNSC. The LIHC box plot shows higher MRFAP1 RNA expression in tumor versus normal tissue (log2 FC = +0.853, t-test p < 0.001).
This table shows molecular features associated with MRFAP1 in patient tissues and cancer cell lines. In patient samples, MRFAP1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, MRFAP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and LUNG_SCLC.
