MRFAP1

Across TCGA patient cohorts, MRFAP1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRFAP1-associated genes across cancer lineages are Akt, Notch1, and STAT3_pY705. Each is linked with MRFAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRFAP1-to-partner and partner-to-MRFAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by MRFAP1-low versus MRFAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRFAP1→partner) and Y-score (partner→MRFAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt →	-0.295	-3.169	.018	.020	3	1
UCEC	Notch1 →	+0.222	+3.169	.004	.020	3	1
UCEC	STAT3_pY705 →	-0.584	-2.999	<.001	.035	3	1
UCEC	Bad_pS112 →	-0.241	-3.169	.018	.020	3	1
UCEC	Gab2 →	+0.502	+3.169	.010	.020	2	1
UCEC	4E-BP1 →	+0.435	+3.029	.003	.018	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Akt by MRFAP1 expression — UCEC

Explore this box plot interactively →