MRFAP1

Across TCGA pan-cancer cohorts, MRFAP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MRFAP1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MRFAP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MRFAP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where MRFAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.785	0.507	<.001	17	view →
LSCC	DFS	Tertile	All	0.538	0.787	.018	11	view →
LUAD	DFS	Quartile	All	0.536	0.853	.010	7	view →
PDAC	DFS	Quartile	All	0.607	0.216	.022	5	view →
OV	DFS	Median	All	0.831	1.000	.012	4	view →
UCEC	DFS	Median	III,IV	0.460	0.889	.044	4	view →
CCRCC	DFS	Median	II,III,IV	0.910	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MRFAP1–HNSC (OS)

Open the HNSC breakdown →