MRFAP1

Across TCGA patient cohorts, MRFAP1 mutation is significantly associated with the RNA expression of many other genes, with 427 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRFAP1-associated genes across cancer lineages are OR4A17P, MIR3118-3, and MIR6072. Each is linked with MRFAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRFAP1-to-partner and partner-to-MRFAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4A17P grouped by MRFAP1-low versus MRFAP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRFAP1→partner) and Y-score (partner→MRFAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR4A17P →	+0.029	+7.731	<.001	.009	3	2
BRCA	MIR3118-3 →	+0.558	+8.471	<.001	.005	3	1
BRCA	MIR6072 →	+0.319	+9.057	<.001	.003	3	1
BRCA	H3P46 →	+0.088	+7.731	<.001	.009	3	1
UCEC	PTPRJ →	+0.673	+2.711	.007	.003	3	1
UCEC	BAG3 →	+0.826	+2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 427 associations by consensus.

OR4A17P by MRFAP1 expression — BRCA

Explore this box plot interactively →