MAGUK p55 scaffold protein 4Genealiases: ALS2CR5 · DLG6
Q-omics provides the consensus-scored MPP4 profile across patient tissues and cancer cell-line models. MPP4 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, MPP4 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, MPP4 RNA expression shows 16,589 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRC, HNSC, and TGCT as cancer lineages where MPP4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MPP4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MPP4 survival associations across molecular data types. MPP4 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (5) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MPP4 RNA expression–survival associations across cancer types. High MPP4 expression shows unfavorable associations in KIRC, KICH, LIHC, ACC, MESO and LGG. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for MPP4 RNA expression.
This table summarizes MPP4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 5. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for MPP4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MPP4 shows higher tumor expression in HNSC, COAD, LIHC, LUSC, ESCA and CHOL. The HNSC box plot shows higher MPP4 RNA expression in tumor versus normal tissue (log2 FC = +0.205, t-test p = .002).
This table shows molecular features associated with MPP4 in patient tissues and cancer cell lines. In patient samples, MPP4 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, MPP4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in BONE and SOFT_TISSUE.
