MPP4

Across TCGA cell cohorts, MPP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,453 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MPP4-associated GO terms across cancer lineages are Serotonin transport, Establishment of epithelial cell apical/basal polarity, and Positive regulation of focal adhesion assembly. Each is linked with MPP4 in more than 10 cancer types. Because this analysis shows association rather than direction, both MPP4-to-partner and partner-to-MPP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Serotonin transport grouped by MPP4-low versus MPP4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP4→partner) and Y-score (partner→MPP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Serotonin transport →	-1.032	-1.303	<.001	<.001	3	11
OVARY	Establishment of epithelial cell apical/basal polarity →	+0.162	+1.237	.005	.008	3	10
BONE	Positive regulation of focal adhesion assembly →	+0.182	+1.531	.001	<.001	3	10
BONE	Positive regulation of cell-substrate junction organization →	+0.137	+1.252	<.001	.001	3	10
LIVER	Actin filament fragmentation →	+0.114	+1.357	.001	.009	3	10
BONE	Positive regulation of stress fiber assembly →	+0.150	+1.295	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,453 associations by consensus.

Serotonin transport by MPP4 expression — SKIN

Explore this box plot interactively →