MPP4

Across TCGA cell cohorts, MPP4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible MPP4-associated genes across cancer lineages are OXT, DYDC1, and TGIF2LY. Each is linked with MPP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPP4-to-partner and partner-to-MPP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by MPP4-low versus MPP4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPP4→partner) and Y-score (partner→MPP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OXT →	+0.513	+4.906	<.001	.006	3	1
OESOPHAGUS	DYDC1 →	+0.146	+4.906	<.001	.006	3	1
OESOPHAGUS	TGIF2LY →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	AADACL3 →	+0.410	+4.906	<.001	.006	3	1
OESOPHAGUS	KRTAP10-7 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	CBLN4 →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OXT by MPP4 expression — OESOPHAGUS

Explore this box plot interactively →