meiosis specific nuclear structural 1Genealiases: CFAP127 · HTX9 · SPATA40
Q-omics provides the consensus-scored MNS1 profile across patient tissues and cancer cell-line models. MNS1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, MNS1 is differentially expressed in 10, with the highest sampling consensus in KICH. Additionally, MNS1 RNA expression shows 19,572 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight ACC, KICH, and KIRP as cancer lineages where MNS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MNS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MNS1 survival associations across molecular data types. MNS1 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (2) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MNS1 RNA expression–survival associations across cancer types. High MNS1 expression shows unfavorable associations in ACC, KICH, LGG and KIRP, but favorable associations in UCS and SKCM. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for MNS1 RNA expression.
This table summarizes MNS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 4. The strongest signals are observed in KICH for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for MNS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MNS1 shows lower tumor expression in KICH, THCA and KIRC and higher tumor expression in BLCA, CHOL and LIHC. The KICH box plot shows higher MNS1 RNA expression in normal versus tumor tissue (log2 FC = −3.605, t-test p < 0.001).
This table shows molecular features associated with MNS1 in patient tissues and cancer cell lines. In patient samples, MNS1 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, MNS1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and BLOOD_Lymphoma.
