MNS1

Across TCGA patient cohorts, MNS1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MNS1-associated genes across cancer lineages are A-Raf_pS299, JNK2, and p38-MAPK. Each is linked with MNS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MNS1-to-partner and partner-to-MNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by MNS1-low versus MNS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MNS1→partner) and Y-score (partner→MNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.105	-3.169	.029	.018	3	1
UCEC	JNK2 →	+0.225	+1.594	.004	.042	3	1
UCEC	p38-MAPK →	-0.174	-1.906	.008	.016	3	1
UCEC	P-Cadherin →	-0.119	-3.311	.041	.010	3	1
UCEC	PCNA →	+0.231	+1.906	.007	.016	3	1
UCEC	Rab25 →	-0.375	-1.906	.004	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

A-Raf_pS299 by MNS1 expression — UCEC

Explore this box plot interactively →