MNS1

Across TCGA cell cohorts, MNS1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MNS1-associated genes across cancer lineages are TBL1Y, ADH1B, and LRIT1. Each is linked with MNS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MNS1-to-partner and partner-to-MNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBL1Y grouped by MNS1-low versus MNS1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MNS1→partner) and Y-score (partner→MNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	ADH1B →	+0.049	+4.192	<.001	.003	3	1
BLOOD_Leukemia	LRIT1 →	+0.032	+4.684	<.001	<.001	3	1
BLOOD_Leukemia	SFT2D3 →	+0.429	+3.450	<.001	.004	3	1
BLOOD_Leukemia	OR10Q1 →	+0.016	+3.969	<.001	.009	3	1
BLOOD_Leukemia	TSSK1B →	+0.012	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TBL1Y by MNS1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →