Q-omics provides the consensus-scored MCM7 profile across patient tissues and cancer cell-line models. MCM7 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, MCM7 is differentially expressed in 16, with the highest sampling consensus in COAD. Additionally, MCM7 protein abundance shows 31,824 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight ACC, COAD, and LSCC as cancer lineages where MCM7 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MCM7 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MCM7 survival associations across molecular data types. MCM7 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (5) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MCM7 RNA expression–survival associations across cancer types. High MCM7 expression shows unfavorable associations in ACC, MESO, KICH, LIHC, LGG and LUAD. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for MCM7 RNA expression.
This table summarizes MCM7 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for MCM7. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MCM7 shows higher tumor expression in COAD, KIRC, HNSC, LUAD, KIRP and BLCA. The COAD box plot shows higher MCM7 RNA expression in tumor versus normal tissue (log2 FC = +1.894, t-test p < 0.001).
This table shows molecular features associated with MCM7 in patient tissues and cancer cell lines. In patient samples, MCM7 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, MCM7 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in SKIN and BLOOD_Leukemia.
