MCM7

Across TCGA patient cohorts, MCM7 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM7-associated genes across cancer lineages are ATM, p70-S6K, and Notch1. Each is linked with MCM7 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCM7-to-partner and partner-to-MCM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MCM7-low versus MCM7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM7→partner) and Y-score (partner→MCM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.594	-2.247	<.001	.001	3	3
BLCA	p70-S6K →	-0.350	-3.000	.029	.036	3	2
UCEC	Notch1 →	+0.146	+1.887	.004	.029	3	2
UCEC	Rab25 →	-0.360	-2.807	.003	.003	3	2
UCEC	4E-BP1 →	+0.312	+3.321	.001	.009	3	2
UCEC	Cyclin-B1 →	+0.538	+1.847	.009	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by MCM7 expression — UCEC

Explore this box plot interactively →