MCM7

Across TCGA cell cohorts, MCM7 mutation is significantly associated with the RNA expression of many other genes, with 158 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCM7-associated genes across cancer lineages are MYH6, OR6B1, and SLC5A7. Each is linked with MCM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM7-to-partner and partner-to-MCM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH6 grouped by MCM7-low versus MCM7-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM7→partner) and Y-score (partner→MCM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MYH6 →	+0.006	+5.000	<.001	.006	3	1
OESOPHAGUS	OR6B1 →	+0.013	+4.906	<.001	.006	3	1
BLOOD_Leukemia	SLC5A7 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
LARGE_INTESTINE	TRIM37 →	+0.593	+3.212	.008	.006	3	1
LARGE_INTESTINE	WRAP73 →	+0.577	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 158 associations by consensus.

MYH6 by MCM7 expression — PANCREAS

Explore this box plot interactively →