MCM7

Across TCGA patient cohorts, MCM7 mutation is significantly associated with the RNA expression of many other genes, with 4,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM7-associated genes across cancer lineages are RNA5SP534, UHRF1, and FANCG. Each is linked with MCM7 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCM7-to-partner and partner-to-MCM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP534 grouped by MCM7-low versus MCM7-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM7→partner) and Y-score (partner→MCM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP534 →	+0.189	+4.639	<.001	.005	3	3
UCEC	UHRF1 →	+0.888	+2.273	<.001	<.001	3	3
UCEC	FANCG →	+0.531	+2.284	<.001	<.001	3	3
UCEC	CORT →	+0.316	+1.684	.003	.003	3	3
UCEC	SYPL1P1 →	+0.070	+1.863	<.001	.008	3	3
COAD	JMJD7 →	+0.290	+3.456	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,138 associations by consensus.

RNA5SP534 by MCM7 expression — BRCA

Explore this box plot interactively →