Q-omics provides the consensus-scored MBOAT1 profile across patient tissues and cancer cell-line models. MBOAT1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, MBOAT1 is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, MBOAT1 RNA expression shows 20,030 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRP, KIRC, and UVM as cancer lineages where MBOAT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MBOAT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MBOAT1 survival associations across molecular data types. MBOAT1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MBOAT1 RNA expression–survival associations across cancer types. High MBOAT1 expression shows unfavorable associations in KIRP, LGG and UVM, but favorable associations in LUAD, BRCA and KIRC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for MBOAT1 RNA expression.
This table summarizes MBOAT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 4. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for MBOAT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MBOAT1 shows lower tumor expression in KIRC and COAD and higher tumor expression in LUAD, STAD, CHOL and BLCA. The KIRC box plot shows higher MBOAT1 RNA expression in normal versus tumor tissue (log2 FC = −0.694, t-test p < 0.001).
This table shows molecular features associated with MBOAT1 in patient tissues and cancer cell lines. In patient samples, MBOAT1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, MBOAT1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Myeloma, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BLOOD_Lymphoma.
