MBOAT1

Across TCGA pan-cancer cohorts, MBOAT1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MBOAT1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MBOAT1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MBOAT1 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, CCRCC, and PDAC are the cancer types where MBOAT1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MBOAT1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.583	<.001	9	view →
CCRCC	All	All	+0.447	<.001	5	view →
PDAC	All	All	−0.445	.012	2	view →
LSCC	Male	All	+0.188	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MBOAT1–COAD

Open the COAD breakdown →