MBOAT1

Across TCGA cell cohorts, MBOAT1 mutation is significantly associated with the mutation status of many other genes, with 1,317 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBOAT1-associated genes across cancer lineages are GCN1, TOPORS, and CEP104. Each is linked with MBOAT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MBOAT1-to-partner and partner-to-MBOAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCN1 grouped by MBOAT1-low versus MBOAT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBOAT1→partner) and Y-score (partner→MBOAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GCN1 →	+2.653	+4.452	.001	.001	1	3
BLOOD_Leukemia	TOPORS →	+4.560	+4.309	.007	.007	1	3
LARGE_INTESTINE	CEP104 →	+2.893	+3.222	.003	.003	1	3
LARGE_INTESTINE	ANK2 →	+1.552	+3.495	.005	.005	1	3
BLOOD_Leukemia	LRRC8D →	+3.823	+4.430	.001	.001	1	3
BLOOD_Leukemia	DNAH3 →	+2.168	+3.970	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,317 associations by consensus.

GCN1 by MBOAT1 expression — BLOOD_Leukemia

Explore this box plot interactively →