MBOAT1

Across TCGA cell cohorts, MBOAT1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBOAT1-associated genes across cancer lineages are IAPP, BPIFB6, and ACER1. Each is linked with MBOAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBOAT1-to-partner and partner-to-MBOAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IAPP grouped by MBOAT1-low versus MBOAT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBOAT1→partner) and Y-score (partner→MBOAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IAPP →	+0.539	+3.906	<.001	.005	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ACER1 →	+0.087	+3.823	.002	.006	3	1
BLOOD_Leukemia	LCE3D →	+0.065	+5.201	<.001	.006	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	TMEM114 →	+0.031	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IAPP by MBOAT1 expression — LARGE_INTESTINE

Explore this box plot interactively →