Q-omics provides the consensus-scored KIAA0040 profile across patient tissues and cancer cell-line models. KIAA0040 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, KIAA0040 is differentially expressed in 12, with the highest sampling consensus in HNSC. Additionally, KIAA0040 RNA expression shows 18,020 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, HNSC, and UVM as cancer lineages where KIAA0040 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KIAA0040 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KIAA0040 survival associations across molecular data types. KIAA0040 RNA expression shows survival associations in the most cancer types (26), followed by mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KIAA0040 RNA expression–survival associations across cancer types. High KIAA0040 expression shows unfavorable associations in LGG, HNSC and SCLC, but favorable associations in KIRC, SKCM and ESCA. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for KIAA0040 RNA expression.
This table summarizes KIAA0040 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for KIAA0040. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KIAA0040 shows lower tumor expression in LUSC, LUAD and KIRP and higher tumor expression in HNSC, COAD and BRCA. The HNSC box plot shows higher KIAA0040 RNA expression in tumor versus normal tissue (log2 FC = +1.482, t-test p < 0.001).
This table shows molecular features associated with KIAA0040 in patient tissues and cancer cell lines. In patient samples, KIAA0040 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, KIAA0040 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Lymphoma, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT.
