KIAA0040

Across TCGA pan-cancer cohorts, KIAA0040 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KIAA0040’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KIAA0040 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KIAA0040 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

HNSC, LUSC, and LUAD are the cancer types where KIAA0040 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIAA0040 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.482	<.001	12	view →
LUSC	Female	II,III,IV	−2.358	<.001	9	view →
LUAD	Female	III,IV	−1.448	<.001	9	view →
COAD	All	II,III,IV	+0.570	<.001	8	view →
KIRP	Male	II,III,IV	−1.169	<.001	7	view →
BRCA	All	III,IV	+0.829	<.001	6	view →
KIRC	Male	II,III,IV	−0.601	<.001	6	view →
KICH	All	All	−0.866	<.001	5	view →
STAD	All	II,III,IV	+0.809	<.001	4	view →
CHOL	All	All	+1.437	.001	3	view →
ESCA	All	All	+0.817	.006	2	view →
PRAD	All	All	−0.345	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KIAA0040–HNSC

Open the HNSC breakdown →