Q-omics provides the consensus-scored KCNRG profile across patient tissues and cancer cell-line models. KCNRG expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, KCNRG is differentially expressed in 10, with the highest sampling consensus in KICH. Additionally, KCNRG RNA expression shows 19,494 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and KICH as cancer lineages where KCNRG shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNRG — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNRG survival associations across molecular data types. KCNRG RNA expression shows survival associations in the most cancer types (22), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNRG RNA expression–survival associations across cancer types. High KCNRG expression shows unfavorable associations in UVM, ESCA and KIRP, but favorable associations in UCEC, LUAD and STAD. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for KCNRG RNA expression.
This table summarizes KCNRG tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for KCNRG. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNRG shows lower tumor expression in KICH, LUAD, LUSC, KIRP and THCA and higher tumor expression in COAD. The KICH box plot shows higher KCNRG RNA expression in normal versus tumor tissue (log2 FC = −0.713, t-test p < 0.001).
This table shows molecular features associated with KCNRG in patient tissues and cancer cell lines. In patient samples, KCNRG shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNRG RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUSC, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Leukemia.
